BIOcoretheorySem 3
BIOINFORMATICS
BIO 3121
Syllabus
- 01Bioinformatics overview
- 02Computational biology and bioinformatics
- 03The digital code of life
- 04Introduction to biological sequence databases
- 05The evolutionary basis of sequence alignment
- 06Detecting ORFs
- 07protein Vs nucletotide sequence alignment
- 08Global and Local alignments
- 09Substitution Matrices
- 10Gaps and Gap penalties
- 11Dynamic programming algorithm
- 12Statistical and Biological significance
- 13Introduction to computational biology
- 14Multiple Sequence Alignment
- 15sequence assembly: Overlap-Layout-Consensus approach
- 16Repetitive elements, assembly issues
- 17PCR Primer Design
- 18Gene finding
- 19Graph theory; chemical graphs and amino acid comparisons
- 20Hierarchial levels of macromolecules
- 21Special structures of nucleic acids, Motifs and domains
- 22symmetry of proteins
- 23HP-lattice model
- 24Secondary structure
- 25Molecular visualization
- 26Protein structure-function relationships
- 27Protein modeling
- 28Structure validation
- 29Evolution; Morphology based cladogram
- 30Building Phylogenetic Trees
- 31Phylogenetic Networks
- 32Bioinformatics: future aspects
References
- David W Mount. 2004. BIOINFORMATICS: Sequence and Genome Analysis. Cold Spring Harbor Laboratory Press
- Andreas D Baxevanis, Gary D. Bader, David S. Wishart. 4th Edn, 2020. BIOINFORMATICS. Wiley Interscience.
Credits Structure
3Lecture
0Tutorial
0Practical
3Total